IR Pharma company logo
  • Company overview
  • Meet the team
  • Why we're different;
  • Technology - The drug development process at IRP; The Drug Evaluation Process; Model systems
  • Portfolio
  • Contact us

  • Methodologies to map
    compound function

    Diary

    IR Pharma will have a presence
    at the following conferences.
    Contact us to arrange
    a meeting with one of the team.




    May 19-24, 2017
    American Thoracic Society
    Annual Conference.
    Washington DC, USA.


    September 9-13, 2017
    European Respiratory Society
    Congress.
    Milan, Italy.


    Integrated approach,
    clinical trials . . .



    IR Pharma capability is based on four main pre-clinical stages that, taken together, represent an integrated drug discovery approach.



    Target Validation Models

    Models provide the means to determine, or confirm, target location and function in rodent tissue, human tissue and cells. This includes:

    • Immuno-localisation of target at tissue and cellular level;
    • evaluation of gene expression profiles;
    • disease model assessment using knock-out and transgenic animals.


    In Vitro Profiling (in rodent and human tissue)

    Methodologies to map compound function at a tissue, cellular and molecular level for both human and rodent include:

    • Isolated tissue bioassay;
    • cellular assays;
    • biochemical assays.


    In Vivo Profiling

    Undertaken in both mechanistic and disease models, it includes:

    • Cellular inflammation and histology;
    • functional physiology;
    • pharmacodynamic models to establish effective dosing regimens.


    Clinically relevant biomarkers

    Linking laboratory to clinical trials through comparison of control and disease samples and functional read-outs in both animal and human studies.